This is really an artistic judgment, not a fact-based have seen it done with good effect with an opening quote set into a square-ish block, about as long as 1/3 of a normal line, right justified, in italics. It was placed in the top right-hand corner above the title, which was a little lower and centered. I don’t recall if the font or the size of the font was the same as the one used in the body of the paper. You could experiment with different fonts and sizes until you get a page layout you naturally there are many other page designs that would be think the important thing is to create a visual impression such that the quote cannot be mistaken for the first sentence of the first might be easier to experiment in PowerPoint, putting the elements (quote, title, body) into separate text boxes which you can move around, re-size, and re-justify individually. You can also change the fonts separately, and the font sizes, italics, bold, etc. box by box very easily in PowerPoint.